The Institute of Medicinal Chemistry (IQM) was founded in 1973 and belongs to the Spanish Research Council (CSIC). The institute is located at the Organic Chemistry Centre “Lora-Tamayo”. We focus our activity on the discovery and optimisation of bioactive molecules for treatment, characterisation and diagnosis of different diseases
We apply chemical approaches to solve biomedical problems that cover a wide variety of pathologies, from cancer to neurodegenerative, infectious and cardiovascular diseases. br>
Our research groups have extensive experience in chemical synthesis, molecular modeling, computational chemistry, study of interactions with biomolecules and nanotechnology
Just out! Researchers from IQM have published a new article entitled "Use of 5,10-Disubstituted Dibenzoazaborines and
Dibenzophosphaborines as Cyclic Supports of Frustrated
Lewis Pairs for the Capture of CO2" in @ChemPhysChem, including front cover!
Ferrer, M, Alkorta, I, Elguero, J, Oliva-Enrich, JM. Use of 5,10-Disubstituted Dibenzoazaborines and Dibenzophosphaborines as Cyclic Supports of Frustrated Lewis Pairs for the Capture of CO2. Chemphyschem. 2022;23 (18):e202200619. doi: 10.1002/cphc.202200619. PubMed PMID:36131592 .
Crisman, E, Duarte, P, Dauden, E, Cuadrado, A, Rodríguez-Franco, MI, López, MG et al.. KEAP1-NRF2 protein-protein interaction inhibitors: Design, pharmacological properties and therapeutic potential. Med Res Rev. 2022; :. doi: 10.1002/med.21925. PubMed PMID:36086898 .
Alcón-Calderón, M, de Lucio, H, García-Soriano, JC, Revuelto, A, de Castro, S, López-Gutiérrez, C et al.. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library. Eur J Med Chem. 2022;243 :114675. doi: 10.1016/j.ejmech.2022.114675. PubMed PMID:36075146 .