The Institute of Medicinal Chemistry (IQM) was founded in 1973 and belongs to the Spanish Research Council (CSIC). The institute is located at the Organic Chemistry Centre “Lora-Tamayo”. We focus our activity on the discovery and optimisation of bioactive molecules for treatment, characterisation and diagnosis of different diseases
We apply chemical approaches to solve biomedical problems that cover a wide variety of pathologies, from cancer to neurodegenerative, infectious and cardiovascular diseases. br>
Our research groups have extensive experience in chemical synthesis, molecular modeling, computational chemistry, study of interactions with biomolecules and nanotechnology
López, JC, Alkorta, I, Macario, A, Blanco, S. Characterizing the n→π* interaction of pyridine with small ketones: a rotational study of pyridine⋯acetone and pyridine⋯2-butanone. Phys Chem Chem Phys. 2022; :. doi: 10.1039/d2cp01611g. PubMed PMID:35713114 .
Homma, D, Taketani, S, Shirai, T, Caytan, E, Roussel, C, Elguero, J et al.. Rotational Behavior of N-(5-Substituted-pyrimidin-2-yl)anilines: Relayed Electronic Effect in Two N-Ar Bond Rotations. J Org Chem. 2022;87 (12):8118-8125. doi: 10.1021/acs.joc.2c00845. PubMed PMID:35657258 .
Alkorta, I, Plane, JMC, Elguero, J, Dávalos, JZ, Acuña, AU, Saiz-Lopez, A et al.. Theoretical study of the NO3 radical reaction with CH2ClBr, CH2ICl, CH2BrI, CHCl2Br, and CHClBr2. Phys Chem Chem Phys. 2022;24 (23):14365-14374. doi: 10.1039/d2cp00021k. PubMed PMID:35642918 .