NanoMedMol

At the Nanomedicine and Molecular Imaging group (NanoMedMol) we like to combine nanotechnology, chemistry and biomedical engineering for the diagnosis and treatment of different diseases.

Our expertise is centred on the bioconjugation of different nanomaterials —Iron Oxide, Gold Nanoparticle, Liposomes and Solid Lipid Nanoparticles— applying organic chemistry reactions to the nanoparticles’ surface. In the diagnosis field, NanoMedMol develops imaging probes for techniques like positron emission tomography (PET), magnetic resonance imaging (MRI), fluorescence and magnetic particle imaging (MPI). In the last years the group have developed a new kind of probe based on extremely small iron oxide nanoparticles core-doped with ⁶⁸Ga. This probe provides simultaneous signal in PET and MRI (positive contrast). Another aspect the group is very active is on the use of bioorthogonal chemistry for in vivo imaging, particularly using tetrazine ligation.

The other area the group is working is on the use of nanomedicine against multiresistant bacteria. We are developing new nanoparticles and functionalisation approaches to deal particularly with the virulence of these bacteria. NanoMedMol belongs to CIBER of pulmonary diseases thus our interest is focused on bacteria like P. Aeruginosa, A. Baumannii and H. Influenzae, which produce some of the most complicate lung infections.

RESEARCH LINES

Multifunctional nanoparticles for the early diagnosis of atherosclerosis.

New approaches for the bioconjugation of nanoparticles.

Bioorthogonal chemistry for in vivo molecular imaging with nanomaterials.

Nanoparticles as new antibiotics.

SELECTED PUBLICATIONS AND PATENTS

(1) Arroyo-Urea, EM, Muñoz-Hernando, M, Leo-Barriga, M, Herranz, F, González-Paredes, A. A quality by design approach for the synthesis of palmitoyl-L-carnitine-loaded nanoemulsions as drug delivery systems. Drug Delivery 2023;30 (1):2179128.

(2) Carregal-Romero, S.; Groult, H.; Cañadas, O.; Gonzalez, N.; Lechuga-Vieco, A..; García-Fojeda, B.; Herranz, F.; Pellico, J.; Hidalgo, A.; Casals, C.; Ruiz-Cabello, J. Delayed alveolar clearance of nanoparticles through control of coating composition and interaction with lung surfactant protein A Biomaterials Advances 2022, 112551

(3) Pellico, J.; Fernández-Barahona, I.; Ruiz-Cabello, J.; Gutiérrez, L.; Muñoz-Hernando, M.; Sánchez-Guisado, M.J.; Aiestaran-Zelaia, I.; Martínez-Parra, L.; Rodríguez, I.; Bentzon, J. and Herranz, F. HAP-Multitag, a PET and Positive MRI Contrast Nanotracer for the Longitudinal Characterization of Vascular Calcifications in Atherosclerosis. ACS Applied Materials & Interfaces 2021, 13, 45279−45290.

(4) Adrover, J.M.†; Pellico, J.†; Fernández-Barahona, I.; Martín-Salamanca, S.; Ruiz-Cabello, J.; Hidalgo, A. and Herranz, F. Thrombo-tag, an in vivo formed nanotracer for the detection of thrombi in mice by fast pre-targeted molecular imaging. Nanoscale. 2020, 12, 22978-22987.

(5) Fernández-Barahona, I.; Gutiérrez, L.; Veintemillas-Verdaguer, S.; Pellico, J.; Morales, M. del P.; Catala, M.; del Pozo, M. A.; Ruiz-Cabello, J.; Herranz, F. Cu-Doped Extremely Small Iron Oxide Nanoparticles with Large Longitudinal Relaxivity: One-Pot Synthesis and in Vivo Targeted Molecular Imaging. ACS Omega 2019, 4 (2), 2719–2727.

(6) Pellico, J.; Fernández-Barahona, I.; Benito, M.; Gaitán-Simón, Á.; Gutiérrez, L.; Ruiz-Cabello, J.; Herranz, F. Unambiguous Detection of Atherosclerosis Using Bioorthogonal Nanomaterials. Nanomedicine Nanotechnology, Biol. Med. 2019, 17, 26–35.

(7) Fernández-Barahona, I.; Muñoz-Hernando, M.; Pellico, J.; Ruiz-Cabello, J.; Herranz, F. Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles. Appl. Sci. 2018, 8 (7), 1098.

(8) Groult, H.; García-Álvarez, I.; Romero-Ramírez, L.; Nieto-Sampedro, M.; Herranz, F.; Fernández-Mayoralas, A.; Ruiz-Cabello, J. Micellar Iron Oxide Nanoparticles Coated with Anti-Tumor Glycosides. Nanomaterials 2018, 8 (8), 567.

(9) Lechuga-Vieco, A. V.; Groult, H.; Pellico, J.; Mateo, J.; Enríquez, J. A.; Ruiz-Cabello, J.; Herranz, F. Protein Corona and Phospholipase Activity Drive Selective Accumulation of Nanomicelles in Atherosclerotic Plaques. Nanomedicine Nanotechnology, Biol. Med. 2018, 14 (3), 643–650.

(10) Pellico, J.; Lechuga-Vieco, A. V; Almarza, E.; Hidalgo, A.; Mesa-Nuñez, C.; Fernández-Barahona, I.; Quintana, J. A.; Bueren, J.; Enríquez, J. A.; Ruiz-Cabello, J.; Herranz, F. In Vivo Imaging of Lung Inflammation with Neutrophil-Specific 68Ga Nano-Radiotracer. Sci. Rep. 2017, 7 (1), 13242.

(11) Velasco, C.; Mateo, J.; Santos, A.; Mota-Cobian, A.; Herranz, F.; Pellico, J.; Mota, R. A.; España, S.; Ruiz-Cabello, J. Assessment of Regional Pulmonary Blood Flow Using 68Ga-DOTA PET. EJNMMI Res. 2017, 7 (1), 7.

(12) Pellico, J.; Llop, J.; Fernández-Barahona, I.; Bhavesh, R.; Ruiz-Cabello, J.; Herranz, F. Iron Oxide Nanoradiomaterials: Combining Nanoscale Properties with Radioisotopes for Enhanced Molecular Imaging. Contrast Media Mol. Imaging 2017, 2017.

(13) Groult, H.; Poupard, N.; Herranz, F.; Conforto, E.; Bridiau, N.; Sannier, F.; Bordenave, S.; Piot, J.-M.; Ruiz-Cabello, J.; Fruitier-Arnaudin, I.; Maugard, T. Family of Bioactive Heparin-Coated Iron Oxide Nanoparticles with Positive Contrast in Magnetic Resonance Imaging for Specific Biomedical Applications. Biomacromolecules 2017, 18 (10).

(14) Pellico, J.; Ruiz-Cabello, J.; Fernández-Barahona, I.; Gutiérrez, L.; Lechuga-Vieco, A. V.; Enríquez, J. A.; Morales, M. P.; Herranz, F. One-Step Fast Synthesis of Nanoparticles for MRI: Coating Chemistry as the Key Variable Determining Positive or Negative Contrast. Langmuir 2017, 33 (39).

(15) Herranz, F.; Morales, M. P.; Rodríguez, I.; Ruiz-Cabello, J. Iron Oxide Nanoparticle-Based MRI Contrast Agents: Characterization and in Vivo Use; 2017.

(16) Pellico, J.; Ruiz-Cabello, J.; Saiz-Alía, M.; del Rosario, G.; Caja, S.; Montoya, M.; Fernández de Manuel, L.; Morales, M. P.; Gutiérrez, L.; Galiana, B.; Enríquez, J. A.; Herranz, F. Fast Synthesis and Bioconjugation of 68Ga Core-Doped Extremely Small Iron Oxide Nanoparticles for PET/MR Imaging. Contrast Media Mol. Imaging 2016, 11 (3), 203–210.

(17) Zahraei, M.; Marciello, M.; Lazaro-Carrillo, A.; Villanueva, A.; Herranz, F.; Talelli, M.; Costo, R.; Monshi, A.; Shahbazi-Gahrouei, D.; Amirnasr, M.; Behdadfar, B.; Morales, M. P. Versatile Theranostics Agents Designed by Coating Ferrite Nanoparticles with Biocompatible Polymers. Nanotechnology 2016, 27 (25).

(18) Marciello, M.; Pellico, J.; Fernandez-Barahona, I.; Herranz, F.; Ruiz-Cabello, J.; Filice, M. Recent Advances in the Preparation and Application of Multifunctional Iron Oxide and Liposome-Based Nanosystems for Multimodal Diagnosis and Therapy. Interface Focus 2016, 6 (6).

(19) Pellico, J.; Ruiz-Cabello, J.; Herranz, F. Microwave-Driven Synthesis of Iron Oxide Nanoparticles for Fast Detection of Atherosclerosis. J. Vis. Exp. 2016, 2016 (109).

(20) Bhavesh, R.; Lechuga-Vieco, A.; Ruiz-Cabello, J.; Herranz, F. T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis. Nanomaterials 2015, 5 (4), 1880–1890.

(21) Pellico, J.; Lechuga-Vieco, A. V; Benito, M.; García-Segura, J. M.; Fuster, V.; Ruiz-Cabello, J.; Herranz, F. Microwave-Driven Synthesis of Bisphosphonate Nanoparticles Allows in Vivo Visualisation of Atherosclerotic Plaque. RSC Adv. 2015, 5 (3), 1661–1665.

(22) Groult, H.; Ruiz-Cabello, J.; Pellico, J.; Lechuga-Vieco, A. V; Bhavesh, R.; Zamai, M.; Almarza, E.; Martín-Padura, I.; Cantelar, E.; Martínez-Alcázar, M. P.; Herranz, F. Parallel Multifunctionalization of Nanoparticles: A One-Step Modular Approach for in Vivo Imaging. Bioconjug. Chem. 2015, 26 (1), 153–160.

(23) Salinas, B.; Ruiz-Cabello, J.; Lechuga-Vieco, A. V.; Benito, M.; Herranz, F. Surface-Functionalized Nanoparticles by Olefin Metathesis: A Chemoselective Approach for in Vivo Characterization of Atherosclerosis Plaque. Chem. – A Eur. 2015, 21 (29).

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