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  Publicaciones y Patentes
 
Publicaciones       Patentes
 
      Publicaciones (2005 - ahora)
 

• Decara, J. M.; Romero-Cuevas, M.; Rivera, P.; Macías González, M.; Vida, M.; Pavón, F. J.; Serrano, A.; Cano, C.; Fresno, N.; Pérez-Fernández, R.; Rodríguez de Fonseca, F.; Suarez, J.
“Elaidyl-sulfamide, a oleylethanolamide-modeled antiobesity drug, reduces body weight gain and plasma colesterol in rats”  
Dis. Model. Mech. 2012, 5, 660-670.

 

• Valero, J.; Van Gool, M.; Pérez-Fernández, R.; Castreño, P.; Sánchez-Quesada, J.; Prados, P.; de Mendoza, J.
“Non-peptidic cell-penetrating agents: Synthesis of oligomeric chiral bicyclic guanidinium vectors”  
Org. Biomol. Chem., 2012, 10, 5417-5430.

 

• Hernandez-Folgado, L.; Cumella, J.M.; Morales, P.; Alkorta, I.; Elguero, J.; Jagerovic, N.
“Tautomerism of hydroxychromenopyrazoles”  
J. Mol. Struct. 2012, 1015, 162-165.

 

• Alonso, M.; Serrano, A.; Vida, M.; Crespillo, A.; Hernandez-Folgado, L.; Jagerovic, N.; Goya, P.; Reyes-Cabello, C.; Perez-Valero, V.; Decara, J.; Macias-Gonzales, M.; Bermudez Silva, F.J.; Suarez, J.; Rodriguez de Fonseca, F. Pavon, F.J.
“Anti-obesity efficacy of LH-21, a cannabinoid CB1 receptor antagonist with poor brain penetration, in diet-induced obese rats”
Br. J. Pharmacol. 2012, 165(7), 2274-2291.

 

• Cumella, J.; Hernandez-Folgado, L.; Giron, R.; Sanchez, E.; Morales, P.; Hurst, D.P.; Gomez-Cañas, M.; Gomez-Ruiz, M.; Pinto, D.C.G.A.; Goya, P.; Reggio, P.H.; Martin, M.I.; Fernandez-Ruiz, J.; Silva, A.M.S.; Jagerovic N.
“Chromenopyrazoles: non-psychoactive and selective CB1 cannabinoid agonists with peripheral antinociceptive properties”  
ChemMedChem 2012, 7(3), 452-463.

 

• Fresno, N.; Perez-Fernandez, R.; Goya, P.; Jimeno, M.L.; Alkorta, I.; Elguero, J.; Menendez-Taboada, L.; Garcia-Granda, S.
“Oxazolidinone cross-alkylation during Evans' asymmetric alkylation reaction” Tetrahedron 2011, 67(47), 9104-9111.  

 

• Perez-Fernandez, R.; Fresno, N.; Macias-Gonzalez, M.; Elguero, J.; Decara, J.; Giron, R.; Rodriguez-Alvarez, A.; Martin, M.I.; Rodriguez de Fonseca, F.; Goya, P.
“Discovery of Potent Dual PPARa Agonists/CB1 Ligands”  
ACS Med. Chem. Lett. 2011, 2(11), 793-797.

 

• Goya, P.; Martin, N.; Roman, P.
“W for tungsten and wolfram”  
Nat. Chem. 2011, 3(4), 336.

 

• Vanthuyne, N.; Roussel, C.; Naubron, J.-V.; Jagerovic, N.; Morales, P.; Alkorta, I.; Elguero, J.
“Determination of the absolute configuration of 1,3,5-triphenyl-4,5-dihydropyrazole enantiomers by a combination of VCD, ECD measurements, and theoretical calculations”
Tetrahedron: Asymmetry (2011), 22(10), 1120-1124.

 

• Oliva, C.G.; Jagerovic, N.; Goya, P.; Alkorta, I.; Elguero, J.; Cuberes, Rosa; Dordal, Alberto
“N-Substituted-1,2,3-triazoles: synthesis, characterization and evaluation as cannabinoid ligands”
ARKIVOC (2010), 2, 127-147.

 

• Hernandez-Folgado, L.; Baretic, D.; Piantanida, I.; Marjanovic, M.; Kralj, M.; Rehm, T.; Schmuck, C. “Guanidiniocarbonylpyrrole-aryl derivatives: structure tuning for spectrophotometric recognition of specific DNA and RNA sequences and for antiproliferative activity”  Chem. Eur. J. (2010), 16(10), 3036-3056.

 

• Alkorta, I.; Blanco, F.; Del Bene, J.E.; Elguero, J.; Hernandez-Folgado, L.; Jimeno, M.-L.
“Difluorobenzenes revisited: an experimental and theoretical study of spin-spin coupling constants for 1,2-, 1,3-, and 1,4-difluorobenzene” Magn. Reson. Chem. (2010), 48(1), 68-73.

 

• Silva, V.L. M.; Silva, A.M.S.; Pinto, D.C.G.A.; Rodriguez, P.; Gomez, M.; Jagerovic, N.; Callado, L.F.; Cavaleiro, J.A.S.; Elguero, J.; Fernandez-Ruiz, J.
“Synthesis and pharmacological evaluation of new (E)- and (Z)-3-aryl-4-styryl-1H-pyrazoles as potential cannabinoid ligands”
ARKIVOC (2010), 10, 226-247.

 

• Cano, C.; Paez, J.A.; Goya, P.; Serrano, A.; Pavon, J.; Rodriguez de Fonseca, F.; Suardiaz, M.; Martin, M.I.
“Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide”
Eur. J. Med. Chem. (2009), 44(12), 4889-4895.

 

• Alkorta, I.; Goya, P.; Perez-Fernandez, R.; Alvarado, M.; Elguero, J.; Garcia-Granda, S.; Menendez-Taboada, L.
“The structure of two pyrazole esters related to Rimonabant”
J. Mol. Struct. (2009), 937(1-3), 10-15.  

 

• Perez-Fernandez, R.; Pittelkow, M.; Belenguer, A.M.; Lane, L.A.; Robinson, C.V.; Sanders, J.K.M.
“Two-phase dynamic combinatorial discovery of a spermine transporter” Chem. Commun. (2009), (25), 3708-3710. 

 

• Dardonville, C., Fernández-Fernández, C., Gibbons, S.L., Jagerovic, N., Nieto, L., Ryan, G., Kaiser, M., Brun, R.

"Antiprotozoal Activity of 1-Phenethyl-4-Aminopiperidine Derivatives"

Antimicrob. Agents Chemother. 2009, 53, 3815-3821.

 

• Alkorta, I., Goya, P., Pérez-Fernández, R., Alvarado, M., Elguero, J., García-Granda, S.,  Menéndez-Taboada, L.

"The structure of two pyrazole esters related to Rimonabant"

J. Mol. Structure  2009,  937,  10-15. 

 

• Alkorta, I., Alvarado, M., Elguero, J., Garcá-Aranda, S., Goya, P., Jimeno, M. L., Menéndez-Taboada, L.
"The structure of Rimonabant in the solid state and in solution: An experimental and theoretical study"

Eur. J. Med. Chem. 2009, 44, 1864-1869.

 

• Alkorta, I., Alvarado, M., Elguero, J., Garcá-Aranda, S., Goya, P., Torre-Fernández, L., Menéndez-Taboada, L..
"Structural study of diarylazoles related to Rimonabant"

J. Mol. Struct. 2009, 920, 82-89.

 

• Jagerovic, N., Fernández-Fernández, C., Goya, P.

"CB1 Cannabinoid antagonists: structure-activity relationships and potential therapeutic applications"

Curr. Top. Med. Chem., 2008, 8, 205-230.

 

• Hernandez-Folgado, L., Goya, P., Frigola, J., Cuberes, M. R., Dordal, A., Holenz, J., Jagerovic, N.

"Novel derivatives of 3-alkyl-1,5-diaryl-1 H - 1,2,4-triazoles and their pharmacological evaluation as CB1 cannabinoid ligands"
Monatsh. Chem. 2008, 139, 1073-1081.

 

• Fernández-Fernández, C., Jagerovic, N., Alkorta, I., Maya, C. M., Infantes, L., Elguero, J.

"The molecular structure of 1,3-dimethyl-4-phenyl-1H-pyrazole-5-carboxylic acid"

Arkivoc, 2008 viii, 74-84.

 

• Pavón, F. J., Serrano, A., Pérez-Valero, V., Jagerovic, N., Hernández-Folgado, L., Macías, M., Goya, P., Rodríguez de Fonseca, F. J.
"Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effect of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in zucker rats"
J. Neuroendocrinology 2008, 20 (suppl. 1), 116-123.

 

• Alvarado, M., Goya, P., Macías-González, M., Pavón F. J., Serrano, A., Jagerovic, N., Elguero, J., Gutierrez-Rodríguez, A., García-Granda, S., Suardaz, M., Rodríguez de Fonseca, F.

"Antiobesity designed multiple ligands: synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents"

Bioorg. Med. Chem. 2008, 16(23), 10105-10105.

 

• Goicoechea, C., Sánchez, E; Cano, C., Jagerovic, N., Martín, M. I.

"Analgesic activity and pharmacological characterization of N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl] propenamide, a new opioid agonist acting peripherally"

Eur. J. Pharmacol. 2007, 595, 22-29.

 

• Alkorta, I., Goya, P., Elguero, J., Singh, S.P.

"A simple approach to the tautomerism of aromatic heterocycles. A Review"

Natl. Acad. Sci. Lett., 2007, 30, 139-159.

 

• Cano, C., Goya, P., Paez, J. A., Giron, R., Sanchez, E., Martin, M. I.

"Discovery of 1,1-dioxo-1,2,6-thiadiazine-5-carboxamide derivatives as cannabinoid-like molecules with agonist and antagonist activity"

Bioorg. Med. Chem., 2007, 15, 7480-7493.

 

• Cano, C., Pavón, J., Serrano, A., Goya, P., Páez, J. A., de Fonseca, F. R., Macias-González, M.

"Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation"

J. Med. Chem., 2007, 50, 389-393.

 

• Silva, V. L. M., Silva, A. M. S., Pinto, D. C .G. A., Jagerovic, N., Callado, L. F., Cavaleiro, J. A. S., Elguero, J.

"Synthesis and pharmacological evaluation of chlorinated N-alkyl-3- and -5-(2-hydroxyphenyl)pyrazoles as CB1 cannabinoid ligands "

Monatsh. Chem. 2007, 138, 97-811.

 

• Pavón F. J., Bilbao A., Hernández-Folgado L., Cippitelli A., Jagerovic N., Abellán G., Rodríguez-Franco M.I., Serrano A., Macias M., Gómez R., Navarro M., Goya P., Rodríguez de Fonseca F.

"Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole - LH 21"

Neuropharmacology, 2006, 51(2), 358-366.

 

• Jagerovic N., Hemandez-Folgado L., Alkorta I., Goya P., Martin M. I., Dannert M. T., Alsasua A., Frigola J., Cuberes M. R., Dordal A., Holenz J.

"Structural-activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides"

Eur. J. Med. Chem., 2006, 41(1), 114-120.

 

• Dardonville, C., Fernández-Fernández, C., Gibbons, S.L., Ryan, G. J., Jagerovic, N., Gabilondo, A., Meana, J.J., Callado, L. F.
"Synthesis, binding and in vivo studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2;-imidazoline binding sites"
Bioorg. Med. Chem. 2006, 14, 6570-6580.

 

• Campillo, N. E., Montero, C., Goya, P., Páez J. A.

"Homology models of the cannabinoid CB1 and CB2 receptors. A docking analysis study"

Eur. J. Med. Chem., 2005, 40, 75 -83.

 
      Patentes
 
• Jagerovic N., Fernández-Fernández C., Goya P., Bermúdez F. J., Rodríguez de Fonseca F., Romero M.
“Bivalent pyrazole derivatives as food intake inhibitors”
Application number: ES200930120; WO2010128191
(Titular entity: Fundación IMABIS/CSIC)

 

• Jagerovic N., Morales P., Goya P., Diaz Laviada I., Vara D., Fernández Ruiz J., Gómez-Ruiz M., Gómez-Cañas M.
“Cromenopirazoldionas como derivados cannabinoides de quinonas con actividad antitumoral”
Application number: ES P201231126
(Titular entity: CSIC/Universidad de Alcala/Universidad Cumplutense de Madrid)

 

• Jagerovic, N.; Cumella Montanchez, J.M.; Goya Laza, M.P.; Fernandez Ruiz, J.; Gomez Ruiz, M.; Rodriguez Valsero, P.
“Chromenopyrazole derivatives as cannabinoid receptor ligands and their preparation and use in the treatment of CB receptor-mediated diseases”
Application number: ES200900802, WO2010109050
(Titular entity: CSIC/UCM)

 

• Bermudez Silva, F.J.; Rodriguez de Fonseca, F.; Romero Cuevas, M.; Jagerovic, N.; Fernandez Fernandez, C.; Goya Laza, M.P.
“Bivalent tetraaryl pyrazole-3-carboxamides, and their preparation and use as food intake inhibitors”
Application number: ES200930120, WO2010128191
(Titular entity: Fundación IMABIS/CSIC)

 

• Rodríguez de Fonseca F., Macías González M., Serrano A., Goya P., Alvarado M.,  Elguero J., Jagerovic N.

"Pyrazole derivatives of fatty acid amides as PPAR-alpha receptor specific activators, preparation method and use of same"

Application number: ES200702691; WOES000653; WO2009050318

(Titular entity: Fundación IMABIS/CSIC)

 

• Jagerovic N., Cumella J. M., Goya P., Dordal A., Cuberes M. R.

"1,2,4-Triazole derivatives as sigma receptor inhibitors"

Application number: WOEP62006; EP20060380291; EP1921073; WO2008055932; MX2009004746 ; US2010004224 ; KR20090087031; JP2010509280

(Titular entity: Lab. Dr. Esteve S.A.)

 

• Jagerovic N., Gómez de la Oliva C. A., Goya P., Dordal A., Cuberes R.

"1,2,3-Triazole derivatives as sigma receptor inhibitors"

Application number: WO2007EP62010; EP2006038029; EP1921073; WO2008055932; MX2009004745; US2010004265; KR20090087032 ; JP2010509281

(Titular entity: Lab. Dr. Esteve S.A.)

 

•Cano C., Pavón F. J., Serrano A., Goya P., Páez J. A., Rodríguez de Fonseca F., Macias M.

"Acyclic sulfamide derivatives"

Application number: ES20060000184, WO2007EP00681, ES2288107, WO20071085469

(Titular entity: Fundación IMABIS/CSIC licensed to Pharmamar)

 

• Páez J. A., Goya P., Cano C., Martín M. I., Girón R., Goicoechea C.

"1,1-Dioxo-1,2,6-thadiazine 2-substituted 5-carboxylate and 5- carboxamide derivatives with cannabinoid properties"

Application number: ES2274729, ES20050002759, WO2006ES70172, WO2007054601

(Titular entity: CSIC/URJC)

 

• Jagerovic N., Fernández Fernández C., Goya P., Callado L. F., Meana J. J.

"Pyrazolecarboxamide derivatives, method of obtaining same and use thereof as inverse antagonists/agonists of the cannabinoid CB1 and opioid m receptor"

Application number: ES2289888; WO2006ES70132; ES20050002196; WO2007028849

(Titular entity: CSIC/UPV)

 

• Jagerovic N. , Gómez de la Oliva C. A., Goya P., Dordal A., Cuberes M.

"1,2,3-Triazole derivatives as cannabinoid-receptor modulators"

Application number: EP20060380290; EP1921072

(Titular entity:Lab Dr Esteve S.A.)

 

• Holenz J., Frigola J., Cuberes R., Dordal A., Goya P., Jagerovic N., Hernández Folgado L., Martin M. I., Alsasua A.
"New 1,2,4-triazole-3-carboxamide derivatives"

Application number: ES2255834; ES200402232; WO2005IB02720; WO2006030285.

(Titular entity: Lab. Dr. Esteve S.A.)

 

• Jagerovic N., Goya P., Hernandez Folgado L., Alcorta I., Martin M. I., Suardiaz M., Dannert M. T.

"1,2,4-Triazole with cannabinoid properties"

Application number: ES2192494; WO03082833; AU2003215687-A1

(Titular entity: CSIC/UCM)

 

• Rodríguez de Fonseca F., Macias M., Serrano A., Goya P., Alvarado M., Elguero J., Jagerovic N.

"Dual peroxisome proliferator activated receptor alpha (PPAR alpha)/cannabinoid receptor ligands"

Application number: ES200702691, WOES000653, WO2009050318

(Titular entity: Fundación IMABIS/CSIC)