Publicaciones

Anteriores 2015

  • “β-Lactam TRPM8 antagonist RGM8-51 displays antinociceptive activity in different animal models.” Martín-Escura, C.;  Medina-Peris, A.;  Spear L.A.;  Torre Martínez, R.;  Olivos-Oré, L.A.;  Barahona, M.A.; González-Rodríguez, S.;  Fernández-Ballester, G.;  Fernández-Carvajal, A.;   Artalejo, A.R.; Ferrer-Montiel, A.;   González-Muñiz, R.  Int. J. Mol. Sci. 2022, 23(5):2692. https://doi.org/10.3390/ijms2305269
  • “TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation.” Izquierdo, C.; Martin-Martinez, M.; Gómez-Monterrey, I.; González-Muñiz, R. Int J. Mol, Sci. 2021, 22(16), 8502. https://doi.org/10.3390/ijms22168502   
  • “DD04107-​Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-​1 as a putative target.” Butron, D.; Zamora-Carreras, H.; Devesa, .; Trevino, M.A.; Abian, O.; Velazquez-Campoy, A.; Bonache, M. A.; Lagartera, L.; Martin-Martinez, M.; Gonzalez-Rodriguez, S.; Baamonde, A.; Fernández-Carvajal, A.; Ferrer-Montiel, A.; Jiménez, M.A.; González Muñiz, R. Bioorg. Chem. 2021, 115, 105231. https://doi.org/10.1016/j.bioorg.2021.105231
  • “Evolution in non-peptide α–helix mimetics on the road to effective protein-protein interaction modulators.“ Algar, S.; Martín-Martínez, M.; González-Muñiz, R. Eur. J. Med. Chem. 2021, 211, 113015; https://doi.org/10.1016/j.ejmech.2020.113015.
  • “Phenylalanine-derived β-Lactam TRPM8 modulators. Configuration effect on the antagonist activity” Bonache, M.A.; Llabrés, P.J.; Martín-Escura, C.; De la Torre-Martínez, R.; Medina-Peris, A.; Gómez-Monterrey, I.; Roa, A.M.; Fernández-Ballester, G.; Ferrer-Montiel, A.; Fernández-Carvajal, A.; González-Muñíz, R. Int. J. Mol. Sci., 2021, 22, 3390; https://doi.org/10.3390/ijms22052370.
  • “Pharmacological Approaches for the Modulation of the Potassium Channel Kv4.x and KChIPs.” P. Cercós, D. A. Peraza, A.Benito-Bueno, P. G. Socuéllamos, A. Aziz-Nignan, D. Arrechaga-Estévez, E. Beato, E. Peña-Acevedo, A. Albert, J. A. González-Vera, Y. Rodríguez, M. Martín-Martínez, C. Valenzuela and M. Gutiérrez-Rodríguez. Int. J. Mol. Sci. 2021, 22(3), 1419; https://doi.org/10.3390/ijms22031419.
  • “Natural Polyhydroxy Flavonoids, Curcuminoids and Synthetic Curcumin Analogs, as α7 nAChRs Positive Allosteric Modulators.” Ximenis, M.; Mulet, J.; Sala, S.; Sala, F.; Criado, M.; González-Muñíz, R. Pérez de Vega, M.J. Int. J.Mol. Sci., 2021, 22, 973. https:// doi.org/10.3390/ijms22020973.                   
  • “Investigational drugs in early phase clinical trials targeting thermoTRP channels.”  Fernández-Carvajal, A.; González-Muñiz, R.; Fernádez-Ballester, G.; Ferrer-Montiel, A. Expert Opin. Inv. Drugs 2020, 29, 1209–1222; https://doi.org/10.1080/13543784.2020.1825680.
  • “Environment-​Sensitive Probes for Illuminating Amyloid Aggregation In Vitro and in Zebrafish” Fueyo-Gonzalez, F.; Gonzalez-Vera, J. A.; Alkorta, I.; Infantes, L.; Jimeno, M. L.; Aranda, P.; Acuna-Castroviejo, D.; Ruiz-Arias, A.; Orte, A.; Herranz, R. ACS Sensors 2020, 5(9), 2792-2799.
  • “Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity.” LLabrés, P.J.; Bonache, M.A.; Martín-Escura, C.; De la Torre-Martínez, R.; Fernández-Carvajal, A.; Fernández-Ballester, G.; Ferrer-Montiel, A.; González-Muñiz, R. Sci. Rep. 2020, 10, 14154.
  • “Naphthalimide-​based macrophage nucleus imaging probes.”Fueyo-Gonzalez, F.; Fernandez-Gutierrez, M.; Garcia-Puentes, D.; Orte, A.; Gonzalez-Vera, J. A.; Herranz, R. Eur. J. Med. Chem. 2020, 200, 112407.
  • “Fluorescence mechanism switching from ICT to PET by substituent chemical manipulation: Macrophage cytoplasm imaging probes.” Fueyo-Gonzalez, F.; Gonzalez-Vera, J. A.; Alkorta, I.; Infantes, L.; Jimeno, M. L.; Fernandez-Gutierrez, M.; Gonzalez-Garcia, M. C.; Orte, A.; Herranz, R. Dyes and Pigments 2020, 175, 108172.
  • “Characterization of Novel Synthetic Polyphenols: Validation of Antioxidant and Vasculoprotective Activities.” Pérez de Vega, M.J. Moreno-Fernádez, S.; Pontes-Quero, G.M.; González-Amor, M.; Vázquez-Lasa, B.; Sabater-Muñoz, B.; Briones, A.M.; Aguilar, M.R.; Miguel, M.; González-Muñiz, R. Antioxidants 2020, 9(9), 787.
  • “Investigational drugs in early phase clinical trials targeting thermoTRP channels.”  Fernández-Carvajal, A.; González-Muñiz, R.; Fernádez-Ballester, G.; Ferrer-Montiel, A. Expert Opin. Inv. Drugs 2020, ASAP, DOI: 10.1080/13543784.2020.1825680.
  • “Smart lanthanide antennas for sensing water.” Fueyo-Gonzalez, F.; Garcia-Fernandez, E.; Martinez, D.; Infantes, L.; Orte, A.; Gonzalez-Vera, J. A.; Herranz, R.  Chem. Commun. 2020, 56(41), 5484-5487.
  • “Peptides in biology and biomedicine: Walking towards the future.” Jiménez, M.A.; González-Muñiz, R. Arch. Biochem. Biophys. 2019,  665, 20-22.          
  • “Recent Progress in TRPM8 modulation: An update.” González-Muñiz, R., Bonache, M.A.; Martín-Escura, C.; Gómez Monterrey, I. Int. J. Mol. Sci. 2019, 20, E2618.       
  • “1-(2’,5’-Dihydroxyphenyl)-3-(2-fluoro-4-methoxyphenyl)-1-propanone: A positive allosteric modulator of a7 nicotinic receptors with analgesic and neuroprotective activity.” Pérez de Vega, M.J.; Fernandez Mendivil, C.; de la Torre Martínez, R.; González-Rodríguez,S.; Mullet, J.; Sala, F.; Sala, S.;Criado,  M.;Moreno-Fernández, S.; Miguel, M.; Fernández-Carvajal, A.; Ferrer-Montiel, A.; García López, M.; González-Muñiz, R. ACS Chem. Neurochem. 2019, 10 (8), 3900-3909.
  • “Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington´s disease treatment.” A. López-Hurtado,  D. A. Peraza, P. Cercós, L. Lagartera, P. González, X. M. Dopazo, R. Herranz, T. González, M. Martín-Martínez, B. Mellström, J. R. Naranjo, C. Valenzuela, M. Gutiérrez-Rodríguez. Sci. Rep. 2019, 9, 1-16.
  • «Advances in the development of non-steroidal mineralocorticoid receptor antagonist” F. L. Pérez-Gordillo, M. J. Jesús Pérez, G. Gerona-Navarro, Y. Rodríguez, D. Álvarez de la Rosa, R. González-Muñiz, M. Martín-Martínez. Capítulo de libro: Aldosterone-Mineralocorticoid Receptor-Cell Biology to Translational Medicine. Ed.   IntechOpen, London, United Kingdom. Editors: Brian Harvey, Frederic Jaisser.  2019, 257-275. ISBN: 978-1-83962-199-4.
  • «Identification of IQM-266, a Novel DREAM Ligand That Modulates KV4 Currents» C. D. A. Peraza, P. Cercós, P. Miaja, Y. G. Merinero, L. Lagartera, P. G. Socuéllamos, C. Izquierdo García, S. A. Sánchez, A. López-Hurtado, M. Martín-Martínez, L. A. Olivos-Oré, J. R. Naranjo, A. R. Artalejo, M. Gutiérrez-Rodríguez, C. Valenzuela. Frontiers Mol. Neurosci. , 2019, 12, 1-69  (ir a revista)
  •  «Recent progress in non-opioid analgesic peptides» M. J. Pérez de Vega, A. Ferrer-Montiel, R. González-Muñiz. Arch. Biochem. Biophys. , 2018, 660, 36-52  (ir a revista) 
  • «Small library of triazolyl polyphenols correlating antioxidant activity and stability with the number and position of hydroxyl groups» M.A. Bonache, S. Moreno-Fernández, M. Miguel, B. Sabater-Muñoz, R. González-Muñiz. ACS Comb. Sci., 2018, 20, 694-699  (ir a revista) 
  • «Repurposing ciclopirox as a pharmacological chaperone for the treatment of congenital erythropoietic porphyria» Urquiza, P.; Lain, A.; Sanz-Parra, A.; Moreno, J.; Bernardo-Seisdedos, G.; Dubus, P.; Gonzalez, E.; Gutierrez-de-Juan, V.; Garcia, S.; Erana, H.; San Juan, I.; Macias, I.; Ben Bdira, F.; Pluta, P.; Ortega, G.; Oyarzabal, J.; Gonzalez-Muniz, R.; Rodriguez-Cuesta, J.; Anguita, J.; Diez, E.; Blouin, J.-M.; de Verneuil, H.; Mato, J. M.; Richard, E.; Falcon-Perez, J. M.; Castilla, J.; Millet, O. Sci. Transl. Med., 2018, 10, eaat7467  (ir a revista) 
  • «Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity» Balsera, B.; Mulet, J.; Sala, S.; Sala, F.; de la Torre, R.; González-Rodríguez, S.; Plata, A.; Naesens, L.; Fernández-Carvajal, A.; Ferrer-Montiel, A.; Criado, M.; Pérez de Vega, M.J.; González-Muñiz, R. Eur. J. Med. Chem. , 2018, 143, 157-165  (ir a revista) 
  • «D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence»  C.; Oliveras, A.; Bartolucci, C.; Muñoz, C.; de la Cruz, A.; Peraza, D. A.; Gimeno, J. R.; Martín-Martínez, M.; Severi, S.; Felipe, A.; Lambiase, P. D.; González, T.; Valenzuela, C.  J. Mol. Cell. Cardiol. , 2017, 110, 61-69  (ir a revista) 
  • «Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities.» García-Mora, P.; Martín-Martínez, M.; Angeles Bonache, M.; González-Muñiz, R.; Peñas, E.; Frias, J.; Martinez-Villaluenga, C.  Food Chem. , 2017, 221, 464-472  (ir a revista) 
  • «Synthesis, high throughput screening and pharmacological characterization of β–lactam derivatives as TRPM8 antagonists»  De la Torre-Martínez, R.; Bonache, M.A.; Pedro J. LLabrés, P.J.; Balsersa, B.; Fernández-Carvajal, A.; Fernández-Ballester, G.; Ferrer-Montiel, A.; M. Jesús Pérez de Vega, M.J.; González-Muñiz, R. Sci. Rep., 2017, 7, 1-13  (ir a revista)
  •  «Disrupting VEGF-VEGFR1 Interaction: De Novo Designed Linear Helical Peptides to Mimic the VEGF13-25 Fragment.»  Balsera, Beatriz; Bonache, M Angeles; Reille-Seroussi, Marie; Gagey-Eilstein, Nathalie; Vidal, Michel; Gonzalez-Muniz, Rosario; Perez de Vega, Maria Jesus Molecules (Basel, Switzerland), 2017, 22, num. 11  (ir a revista) 
  • «Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.» Martin-Martinez, Mercedes; Perez-Gordillo, Felipe L; Alvarez de la Rosa, Diego; Rodriguez, Yoel; Gerona-Navarro, Guillermo; Gonzalez-Muniz, Rosario; Zhou, Ming-Ming. Journal of medicinal chemistry, 2017, 60, 2629-2650  (ir a revista) 
  • «β-Lactams through single bond ring closing: methods, transformations and bioactivity, capítulo del libro Beta Lactams: Novel Synthetic Pathways and Applications (Springer, NY). B. Banik, Ed. Martín-Torres, I.; González-Muñiz, R.  Capítulo de libro: Beta Lactams: Novel Synthetic Pathways and Applications. Banik, B. Ed. Springer-Nature. 2017, 219-252. ISBN 978-3-319-55621-5.
  • «Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer.» Perez de Vega, M Jesus; Gomez-Monterrey, Isabel; Ferrer-Montiel, Antonio; Gonzalez-Muniz, Rosario. Journal of medicinal chemistry, 2016, 59, 10006-10029   ISSN:1520-4804.
  • «Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease» Naranjo, J.R.; Zhang, H.; Villar, D.; González, P.;Dopazo, X.M.; Morón-Oset, J.; Higueras, E.; Oliveros, J.C.; Arrabal, M.D.; Prieto, A.; Cercós, P.; González, T.; De la Cruz, A.; Casado-Vela, J.; Rábano, A.; Valenzuela, C.; Gutierrez-Rodriguez, M.; Li, J. Y.; Mellström, B. J. Clin. Invest., 2016, 126, 627-638  (ir a revista) 
  • «Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes.» Gonzalez-Vera, Juan A; Fueyo-Gonzalez, Francisco; Alkorta, Ibon; Peyressatre, Marion; Morris, May C; Herranz, Rosario. Chemical communications (Cambridge, England), 2016, 52, 9652-0655  (ir a revista) 
  • «Tryptamine-based derivatives as Transient Receptor Potential Melastatin type-8 (TRPM8) channel modulators.» A. Bertamino, C. Ostacolo, P. Ambrosino, S. Musella, V. Di Sarno, T. Ciaglia, M.V. Soldovieri, N. Iraci, A. Fernández Carvajal, R. De la Torre, A. Ferrer-Montiel, R. González-Muñiz, E. Novellino , M. Taglialatela, P. Campiglia, I. Gómez-Monterrey. J. Med. Chem., 2016, 59, 2179–2191    
  • «1,3-Diphenylpropan-1-ones as Allosteric Modulators of α7 nACh Receptors with Analgesic and Antioxidant Properties»  M. Criado*, B. Balsera, J. Mulet, S. Sala, F. Sala, R. de la Torre-Martínez, A. Fernández-Carvajal, A. Ferrer-Montiel, S. Moreno-Fernández, M. Miguel, M. J. Pérez de Vega, R. González-Muñiz, Future Med. Chem, 2016, 8, 731-749   (ir a revista) 
  • «New transient receptor potential TRPV1, TRPM8 and TRPA1 channel antagonists from a single linear beta,gamma-diamino ester scaffold» Perez-Faginas, P; Aranda, MT; de la Torre-Martinez, R; Quirce, S; Fernandez-Carvajal, A; Ferrer-Montiel, A; Gonzalez-Muniz, R
    RSC ADVANCES, 2016, 6, 6868-6877  (ir a revista) 
  • «Pharmacology of TRP Channels» A. Fernández –Carvajal, G. Fernandez-Ballester, R. González-Muñiz, A. Ferrer-MontielTRP Channels in Sensory Transduction (Springer, NY). R. Madrid, J. Bacigalupo, Eds., 2015, , 41-71  (ir a revista) 
  • «From Multiple PAR1 Receptor/Protein Interactions to their Multiple Therapeutic Implications» Gutierrez-Rodriguez, M; Herranz, R. CURRENT TOPICS IN MEDICINAL CHEMISTRY