Currently, the only approved therapeutics for the treatment of Chagas disease are two nitroheterocyclic compounds, a nitrofuran (nifurtimox; Lampit) and a nitroimidazole (benznidazol; Rochagan) although in the United States these drugs are not approved by FDA (Food and Drug Administration) and are available only from Centers for Disease Control and Prevention (CDC) under investigational drug protocols. The production of nifurtimox was discontinued in 1997, first in Brazil, and then in Argentina, Chile and Uruguay. Currently, benznidazole is the only treatment commercialy available in most endemic countries. Two other alternative drugs for Chagas disease treatment are allopurinol and itraconazole that have been used in some selected cases and in certain conditions.