Docking studies with the most representative cannabinoids described as partial agonists or antagonists/inverse agonists, were performed using Flexidock program. FlexiDock software performs flexible docking using genetics algorithms. The results of these studies confirmed the existence of two binding sites on both CB1 and CB2. While in the CB1 receptor was observed a clear overlap of both sites, in CB2 receptor are clearly distinct. In both sites, receptor-ligand interactions are governed by a combination of hydrogen bonds and aromatic interactions. The results of these studies confirmed the existence of two binding sites on both receptors.