• Inhibidores de la replicación de otros virus

GROUP OF NUCLEOSIDES AND ANALOGUES as a source of bioactive molecules

INHIBITORS OF THE REPLICATION OF OTHER VIRUSES

Human cytomegalovirus (HCMV) and Varicella Zoster (VZV)

Parallel to the line directed to the discovery of anti-AIDS agents, our research group, in collaboration with the Rega Institute for Medical Research (KU Leuven, Belgium), is interested in the discovery of new antivirals against a wide panel of DNA and RNA viruses. We have discovered two new families of potent and specific inhibitors of Human Cytomegalovirus (HCMV) and Varicella Zoster (VZV) replication. The compounds do not show cross-resistance against viral resistant strains to the clinically used drugs, which suggests that the compounds may act by different mechanisms of antiviral action that are currently under study.

Relevant publications::

Enteroviruses

Enteroviruses are responsible of a broad spectrum of acute and chronic human diseases, including respiratory infections, myocarditis and neonatal sepsis, and there are no drugs approved against them. We have described that 9-arylpurines are efficient and selective inhibitors of enterovirus replication, in particular against CVB3. Studies on the mechanism of action of these compounds strongly point towards the assembly of the viral particles as the main target. .

enterovirus

Relevant publications:

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