INHIBITORS OF THE REPLICATION OF OTHER VIRUSES
Human cytomegalovirus (HCMV) and Varicella Zoster (VZV)
Parallel to the line directed to the discovery of anti-AIDS agents, our research group, in collaboration with the Rega Institute for Medical Research (KU Leuven, Belgium), is interested in the discovery of new antivirals against a wide panel of DNA and RNA viruses. We have discovered two new families of potent and specific inhibitors of Human Cytomegalovirus (HCMV) and Varicella Zoster (VZV) replication. The compounds do not show cross-resistance against viral resistant strains to the clinically used drugs, which suggests that the compounds may act by different mechanisms of antiviral action that are currently under study.
Relevant publications::
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2008 - de Castro, S.; Peromingo, M. T.; Naesens, L.; Andrei, G.; Snoeck, R.; Balzarini, B.; Velázquez, S.; Camarasa, M. J.
4”-Benzoylureido-TSAO derivatives as Potent and Selective Non-Nucleoside HCMV Inhibitors. Structure-Activity Relationship and Mechanism of Antiviral Action. J. Med. Chem. 2008, 51, 5823-5832.
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2009 - de Castro, S.; García-Aparicio, C.; Andrei, G.; Snoeck, R.; Balzarini, J.; Camarasa, M. J.; Velázquez, S.
4-Benzyloxy-γ-Sultone Derivatives: Discovery of a Novel Family of Non-Nucleoside Inhibitors of Human Cytomegalovirus (HCMV) and Varicella-Zoster Virus (VZV). J. Med. Chem. 2009, 52, 1582-1591.