Publications


Books and special issues of scientific journals




"Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential."
de la Fuente Revenga, Mario; Fernandez-Saez, Nerea; Herrera-Arozamena, Clara; Morales-Garcia, Jose A; Alonso-Gil, Sandra; Perez-Castillo, Ana; Caignard, Daniel-Henri; Rivara, Silvia; Rodriguez-Franco, Maria Isabel
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58, 4998-5014 (ir a revista)
This work received the honour of being the subject of the Cover of the Journal of Medicinal Chemistry for its issue of July 23, 2015 (http://pubs.acs.org/toc/jmcmar/58/14).
"Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-beta-carboline (Pinoline) and Melatonin-Pinoline Hybrids."
de la Fuente Revenga, Mario; Perez, Concepcion; Morales-Garcia, Jose A; Alonso-Gil, Sandra; Perez-Castillo, Ana; Caignard, Daniel-Henri; Yanez, Matilde; Gamo, Ana M; Rodriguez-Franco, Maria Isabel
ACS CHEMICAL NEUROSCIENCE, 2015, 6, Número:5, Páginas:800-10 (ir a revista)
This work received the honour of being the Cover of ACS Chemical Neuroscience in its issue of May 2015 (http://pubs.acs.org/toc/acncdm/6/5)
"New Tacrine-4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer´s Disease, with Cholinergic, Antioxidant, and beta-Amyloid-Reducing Properties"
Fernandez-Bachiller, MI; Perez, C; Monjas, L; Rademann, J; Rodriguez-Franco, MI
JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55, 1303-1317 (ir a revista)
This work received a diploma as one of the most cited articles of 2012 of the J. Med. Chem. It was ranked in the 9th position of a total of 934 published works (including reviews), being the first of this list that was leaded by a Spanish group.




"Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects" 
Garcia, AM; Brea, J; Gonzalez-Garcia, A; Perez, C; Cadavid, MI; Loza, MI; Martinez, A; Gil, C
MOLECULES201722, número 9  (ir a revista) 

"The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis" 
Perez-Domper, P; Palomo, V; Gradari, S; Gil, C; de Ceballos, ML; Martinez, A; Trejo, JL
NEUROPHARMACOLOGY2017116, 174-187  (ir a revista) 

"3-(Benzyloxy)-1-(5-[18F]fluoropentyl)-5-nitro-1H-indazole: a PET radiotracer to measure acetylcholinesterase in brain" 
Soledad Fernández , Javier Giglio, Ana Laura Reyes, Andrés Damián, Concepción Pérez, Daniel I Pérez, Mercedes González, Patricia Oliver, Ana Rey , Henry Engler, Hugo Cerecetto
FUTURE MEDICINAL CHEMISTRY20179, 983-994   

"Cannabinoid derivatives exert a potent anti-myeloma activity both in vitro and in vivo" 
Barbado, M. V.; Medrano, M.; Caballero-Velazquez, T.; Alvarez-Laderas, I.; Sanchez-Abarca, L. I.; Garcia-Guerrero, E.; Martin-Sanchez, J.; Rosado, I. V.; Piruat, J. I.; Gonzalez-Naranjo, P.; Campillo, N. E.; Paez, J. A.; Perez-Simon, J. A.
INTERNATIONAL JOURNAL OF CANCER2017140, 674-685   

"Subtly Modulating Glycogen Synthase Kinase 3 beta: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases" 
Palomo, V; Perez, DI; Roca, C; Anderson, C; Rodriguez-Muela, N; Perez, C; Morales-Garcia, JA; Reyes, JA; Campillo, NE; Perez-Castillo, AM; Rubin, LL; Timchenko, L; Gil, C; Martinez, A
JOURNAL OF MEDICINAL CHEMISTRY201760, 4983-5001  (ir a revista) 

"The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro" 
Morales-García, J.A.; de la Fuente-Revenga, M.; Alonso-Gil, S.; Rodríguez-Franco, M. I.; Feilding, A.; Pérez-Castillo, A.; Riba, J.
Sci. Rep. 201720177, Article number: 5309  (ir a revista) 

"Hybridizing Feature Selection and Feature Learning Approaches in QSAR Modeling for Drug Discovery" 
Ponzoni, I; Sebastian-Perez, V; Requena-Triguero, C; Roca, C; Martinez, MJ; Cravero, F; Diaz, MF; Paez, JA; Arrayas, RG; Adrio, J; Campillo, NE
SCIENTIFIC REPORTS20177, artículo 2403  (ir a revista) 

"Enzymatic and solid-phase synthesis of new donepezil-based L-and D-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer ' s disease and cerebral ischemia" 
Monjas, L; Arce, MP; Leon, R; Egea, J; Perez, C; Villarroya, M; Lopez, MG; Gil, C; Conde, S; Rodriguez-Franco, MI
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY2017130, 60 - 72  (ir a revista) 

"Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and invivo biological properties." 
Guerra, Angela; Gonzalez-Naranjo, Pedro; Campillo, Nuria E; Varela, Javier; Lavaggi, Maria L; Merlino, Alicia; Cerecetto, Hugo; Gonzalez, Mercedes; Gomez-Barrio, Alicia; Escario, Jose A; Fonseca-Berzal, Cristina; Yaluf, Gloria; Paniagua-Solis, Jorge; Paez, Juan A
European journal of medicinal chemistry2017136, 223 - 234  (ir a revista) 

"Optimization of bicyclic lactam derivatives as NMDA receptor antagonists" 
Espadinha, M.; Dourado, J.; Lajarín-Cuesta, R.; Herrera-Arozamena, C.; Gonçalves, L.; Rodríguez-Franco, M. I.; de los Ríos, C.; Santos, M. M. M.
ChemMedChem201712, 537-545  (ir a revista) 

"Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome" 
Mansilla, A; Chaves-Sanjuan, A; Campillo, NE; Semelidou, O; Martinez-Gonzalez, L; Infantes, L; Gonzalez-Rubio, JM; Gil, C ; Conde, S; Skoulakis, EMC; Ferrus, A; Martinez, A; Sanchez-Barrena, MJ
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA2017114 num. 6, E999-E1008  (ir a revista) 

"New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties" 
Estrada, M; Herrera-Arozamena, C; Perez, C; Vina, D; Romero, A; Morales-Garcia, JA; Perez-Castillo, A; Rodriguez-Franco, (Isabel Rodriguez-Franco, Maria)[ 1 ]
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY2016121, 376-386  (ir a revista) 

"Recent advances in neurogenic small molecules as innovative treatments for neurodegenerative diseases" 
Herrera-Arozamena, C.; Martí-Marí, O.; Estrada, M.; de la Fuente Revenga, M.; Rodríguez-Franco, M. I.
Molecules201621(9), 1165-1185  (ir a revista) 

"New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with sigma-1 agonism and beta-secretase inhibition" 
Estrada, Martin; Perez, Concepcion; Soriano, Elena; Laurini, Erik; Romano, Maurizio; Pricl, Sabrina; Morales-Garcia, Jose A; Perez-Castillo, Ana; Rodriguez-Franco, Maria Isabel
Future medicinal chemistry20168 nº11, 1191-207  (ir a revista) 

"New cinnamic – N-benzylpiperidine and cinnamic – N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties" 
Estrada, M.; Herrera-Arozamena, C.; Pérez, C.; Viña, D.; Romero, A.; Morales-García, J. A.; Pérez-Castillo, A.; Rodríguez-Franco, M. I.
European Journal of Medicinal Chemistry2016121, 376-386  (ir a revista) 
Free access to this article until July 24, 2016: http://authors.elsevier.com

"Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease" 
Chlebek, J; Novak, Z; Kassemova, D; Safratova, M; Kostelnik, J; Maly, L; Locarek, M; Opletal, L; Host'alkova, A; Hrabinova, M ; Kunes, J; Novotna, P; Urbanova, M; Novakova, L; Macakova, K; Hulcova, D; Solich, P; Martin, CP; Jun, D; Cahlikova, L
CHEMISTRY & BIODIVERSITY201613, 91-99  (ir a revista) 

"Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from corydalis cava (fumariaceae) as Alzheimer's disease targets" 
Chlebek, J.; De Simone, A.; Hošťálková, A.; Opletal, L.; Pérez, C.; Pérez, D.I.; Havlíková, L.; Cahlíková, L.; Andrisano, V.
Fitoterapia2015109, 241-247   

"1,2-stereochemical induction in the PdII- catalyzed conjugate addition of boronic acids" 
Roscales, S.; Sánchez, F.; Csákÿ, A.G
European Journal of Organic Chemistry20152015 (8), 1754-1763  (ir a revista) 

"PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis" 
Mestre, L.; Redondo, M.; Carrillo-Salinas, F.J.; Morales-García, J.A.; Alonso-Gil, S.; Pérez-Castillo, A.; Gil, C.; Martínez, A.; Guaza, C.
British Journal of Pharmacology2015172 (17), 4277-4290   

"Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations" 
De La Fuente Revenga, M.; Balle, T.; Jensen, A.A.; Frølund, B.
European Journal of Medicinal Chemistry2015102, 352-362   

"3-Amidocoumarins as Potential Multifunctional Agents Against Neurodegenerative Diseases" 
Matos, M. J.; Rodríguez-Enríquez, F.; Borges, F.; Santana, L.; Uriarte, E.; Estrada, M.; Rodríguez-Franco, M. I.; Laguna, R.; Viña, D.
ChemMedChem 2015201510, 2071-2079  (ir a revista) 

"New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization." 
de la Fuente Revenga, Mario; Herrera-Arozamena, Clara; Fernandez-Saez, Nerea; Barco, Gema; Garcia-Orue, Itxaso; Sugden, David; Rivara, Silvia; Rodriguez-Franco, Maria Isabel
European journal of medicinal chemistry2015103, 370-3  (ir a revista) 

"Supercritical fluid extraction of grape seeds: extract chemical composition, antioxidant activity and inhibition of nitrite production in LPS-stimulated Raw 264.7 cells" 
Perez, C; Ruiz del Castillo, ML; Gil, C; Patricia Blanch, G; Flores, G
FOOD & FUNCTION20156, 2607-2613  (ir a revista) 

"Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential." 
de la Fuente Revenga, Mario; Fernandez-Saez, Nerea; Herrera-Arozamena, Clara; Morales-Garcia, Jose A; Alonso-Gil, Sandra; Perez-Castillo, Ana; Caignard, Daniel-Henri; Rivara, Silvia; Rodriguez-Franco, Maria Isabel
Journal of medicinal chemistry201558, 4998-5014  (ir a revista) 

"Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-beta-carboline (Pinoline) and Melatonin-Pinoline Hybrids." 
de la Fuente Revenga, Mario; Perez, Concepcion; Morales-Garcia, Jose A; Alonso-Gil, Sandra; Perez-Castillo, Ana; Caignard, Daniel-Henri; Yanez, Matilde; Gamo, Ana M; Rodriguez-Franco, Maria Isabel
ACS chemical neuroscience20156,  Número:5, Páginas:800-10  (ir a revista) 

"Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity" 
Silva, T; Bravo, J; Summavielle, T; Remiao, F; Perez, C; Gil, C; Martinez, A; Borges, F
RSC ADVANCES20155, 15800-15811  (ir a revista) 

"Novel Tacrine-Grafted Ugi Adducts as Multipotent Anti-Alzheimer Drugs: A Synthetic Renewal in Tacrine-Ferulic Acid Hybrids" 
Benchekroun, M.; Bartolini, M.; Egea, J.; Romero, A.; Soriano, E.; Pudlo, M.; Luzet, V.; Andrisano, V.; Jimeno, M. L.; López, M. G.; Wehle, S.; Gharbi, T.; Refouvelet, B.; de Andrés, L.; Herrera-Arozamena, C.; Monti, B.; Bolognesi, M. L.; Rodríguez-Franco, M. I.; Decker, M.; Marco-Contelles, J.; Ismaili, L.
ChemMedChem201510, 523-539  (ir a revista) 

"The melatonin – N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer’s model via hemo-oxygenase-1 induction" 
Buendía, I.; Egea, J.; Parada, E.; Navarro, E.; León, R.; Rodríguez-Franco, M. I.; López, M. G.
ACS Chemical Neuroscience20156, 288-296  (ir a revista) 

"Potent and selective MAO-B inhibitory activity: amino- versus nitro-3-arylcoumarin derivatives" 
Matos, M. J.; Rodríguez-Enríquez, F.; Vilar, S.; Santana, L.; Uriarte, E.; Hripcsak, G.; Estrada, M.; Rodríguez-Franco, M. I.; Viña, D.
Bioorganic and Medicinal Chemistry Letters201525, 642-648   (ir a revista) 

"CB1 blockade potentiates down-regulation of lipogenic gene expression in perirenal adipose tissue in high carbohydrate diet-induced obesity" 
Vida, M.; Rivera, P.; Gavito, A. L.; Suárez, J.; Pavón, F. J.; Arrabal, S.; Romero-Cuevas, M.; Bautista, D.; Martínez, A.; Rodríguez De Fonseca, F.; Serrano, A.; Baixeras, E.
PLoS ONE20149(2),    

"Guanidinium-based derivatives: Searching for new kinase inhibitors" 
Diez-Cecilia, E.; Kelly, B.; Perez, C.; Zisterer, D.M.; Nevin, D. K.; Lloyd, D. G.; Rozas, I.
European Journal of Medicinal Chemistry201481, 427-441   

"N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual" 
Bautista-Aguilera, OM; Samadi, A; Chioua, M; Nikolic, K; Filipic, S; Agbaba, D; Soriano, E; de Andres, L; Rodriguez-Franco, MI; Alcaro, S; Ramsay, RR; Ortuso, F; Yanez, M; Marco-Contelles, J
JOURNAL OF MEDICINAL CHEMISTRY201457, 10455-10463  (ir a revista) 

"ITH12410/SC058: A New Neuroprotective Compound with Potential in the Treatment of Alzheimer's Disease" 
Romero, A; Egea, J; Gonzalez-Munoz, GC; de Saavedra, MDM; del Barrio, L; Rodriguez-Franco, MI; Conde, S; Lopez, MG; Villarroya, M; de los Rios, C
ACS CHEMICAL NEUROSCIENCE20145, 770-775  (ir a revista) 

"N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor" 
Bautista-Aguilera, O.M.; Samadi, A.; Chioua, M.; Nikolic, K.; Filipic, S.; Agbaba, D.; Soriano, E.; de Andrés, L.; Rodríguez-Franco, M.I.; Alcaro, S.; Ramsay, R.R.; Ortuso, F.; Yañez, M.; Marco-Contelles, J.
Journal of Medicinal Chemistry201457, 10455-10463  (ir a revista) 

"Modulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors" 
Ana M. García, José Brea, Jose A. Morales-García, Daniel I. Perez, Alejandro González, Sandra Alonso-Gil, Irene Gracia-Rubio, Clara Ros-Simó, Santiago Conde, María Isabel Cadavid, María Isabel Loza, Ana Perez-Castillo, Olga Valverde, Ana Martinez, Carmen Gil
J. Med. Chem.201457, 8590-8607  (ir a revista) 

"ITH12410/SC058: A new neuroprotective compound with potential in the treatment of Alzheimer´s disease" 
Romero, A.; Egea, J.; González-Muñoz, G. C.; Martín de Saavedra, M. D.; del Barrio, L.; Rodríguez-Franco, M. I.; Conde, S.; López, M. G.; Villarroya, M.; de los Ríos, C.
ACS Chemical Neuroscience20145 (9), 770-775  (ir a revista) 

"New Melatonin-N,N-Dibenzyl(N-methyl)amine Hybrids: Potent Neurogenic Agents with Antioxidant, Cholinergic, and Neuroprotective Properties as Innovative Drugs for Alzheimer's Disease" 
Lopez-Iglesias, B; Perez, C; Morales-Garcia, JA; Alonso-Gil, S; Perez-Castillo, A; Romero, A; Lopez, MG; Villarroya, M; Conde, S; Rodriguez-Franco, MI
JOURNAL OF MEDICINAL CHEMISTRY201457, 3773-3785  (ir a revista) 

"Discovery of 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide as a potential neuroprotectant for Alzheimer’s disease by hybridization of curcumin and melatonin" 
Chojnacki, J. E.; Liu, K.; Yan, X.; Toldo, S.; Selden, T.; Estrada, M.; Rodríguez-Franco, M. I.; Halquist, M. S.; Ye, D.; Zhang, S.
ACS Chemical Neuroscience20145 (8), 690-699  (ir a revista) 

"Phosphodiesterase 10 Inhibitors: New Disease Modifying Drugs for Parkinson's Disease?" 
Garcia, AM; Redondo, M; Martinez, A; Gil, C
CURRENT MEDICINAL CHEMISTRY201421, 1171-1187   ISSN electrónico: 1875-533X

"Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis" 
Salado, IG; Redondo, M; Bello, ML; Perez, C; Liachko, NF; Kraemer, BC; Miguel, L; Lecourtois, M; Gil, C; Martinez, A; Perez, DI
JOURNAL OF MEDICINAL CHEMISTRY201457, 2755-2772  (ir a revista) 

"Crosstalk between Phosphodiesterase 7 and Glycogen Synthase Kinase-3: Two Relevant Therapeutic Targets for Neurological Disorders" 
Morales-Garcia, JA; Palomo, V; Redondo, M; Alonso-Gil, S; Gil, C; Martinez, A; Perez-Castillo, A
ACS CHEMICAL NEUROSCIENCE20145, 194-204  (ir a revista) 

"Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease" 
Gonzalez-Naranjo, P; Perez-Macias, N; Campillo, NE; Perez, C; Aran, VJ; Giron, R; Sanchez-Robles, E; Martin, MI; Gomez-Canas, M; Garcia-Arencibia, M; Fernandez-Ruiz, J; Paez, JA
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY201473, 56-72  (ir a revista) 

"Glycogen Synthase Kinase-3 Inhibitors Reverse Deficits in Long-term Potentiation and Cognition in Fragile X Mice" 
Franklin, AV; King, MK; Palomo, V; Martinez, A; McMahon, LL; Jope, RS
BIOLOGICAL PSYCHIATRY201475, 198-206  (ir a revista) 

"Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases" 
González-Muñoz, G. C.; Arce, M. P.; Pérez, C.; Romero, A.; Villarroya, M.; López, M. G.; Conde, S.; Rodríguez-Franco, M. I.
Eur. J. Med. Chem201481, 350-358  (ir a revista) 

"New melatonin – N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer’s disease." 
López-Iglesias, B.; Pérez, C.; Morales-García, J. A.; Alonso-Gil, S.; Pérez-Castillo, A.; Romero, A.; López, M. G.; Villarroya, M.; Conde, S.; Rodríguez-Franco, M. I.
Journal of Medicinal Chemistry201457, 3773-3785  (ir a revista) 

"Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin" 
Bidon-Chanal, A.; Fuertes, A.; Alonso, D.; Pérez, D.I.; Martínez, A.; Luque, F.J.; Medina, M.
Eur. J. Med. Chem201360, 479-489  (ir a revista) 

"Methyl jasmonate treatment of strawberry fruits enhances antioxidant activity and the inhibition of nitrite production in LPS-stimulated Raw 264.7 cells" 
Flores, G.; Pérez, C.; Gil, C.; Blanch, G. P.; Ruiz del Castillo, M. L.
J. Funct. Foods20135, 1803-1809  (ir a revista) 

"Isolation and First Total Synthesis of PM050489 and PM060184, Two New Marine Anticancer Compounds" 
Martín, M.J.; Coello, L.; Fernández, R.; Reyes, F.; Rodríguez, A.; Murcia, C.; Garranzo, M.; Mateo, C.; Sánchez-Sancho, F.; Bueno, S.; de Eguilior, C.; Francesch, A.; Munt, S.; Cuevas. C.
J. Am. Chem. Soc2013135, 10164−10171  (ir a revista) 

"PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice" 
Lorrio, S.; Romero, A.; González-Lafuente, L.; Lajarín-Cuesta, R.; Martínez-Sanz, F. J.; Estrada, M.; Samadi, A.; Marco-Contelles, J.; Rodríguez-Franco, M. I.; Villarroya, M.; López, M. G.; de los Ríos, C.
ACS Chem. Neurosci20134, 1267-1277  (ir a revista) 

"Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia" 
Lorrio, S.; Gómez-Rangel, V.; Negredo, P.; Egea, J.; León, R.; Romero, A.; Dal-Cim, T.; Villarroya, M.; Rodríguez-Franco, M. I.; Conde, S.; Arce, M. P.; Roda, J. M.; García, A. G.; López, M. G.
Neuropharmacology201367, 403-411  (ir a revista) 

"Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities" 
Redondo, M; Soteras, I; Brea, J; Gonzalez-Garcia, A; Cadavid, MI; Loza, MI; Martinez, A; Gil, C; Campillo, NE
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY201370, 781-788  (ir a revista) 

"Oligodendrocyte precursor cells from adult human brains are heterogeneous: effects of FGF-2, anosmin-1 and inhibitors of endogenous phosphodiesterase 7" 
de Castro, F; Medina-Rodriguez, EM; Ortega, MC; Esteban, PF; Pastor, J; de Sola, RG; Gil, C; Martinez, A; Clemente, D; Bribian, A
MULTIPLE SCLEROSIS JOURNAL201319, 164-164    ISSN: 1352-4585

"Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis" 
Gonzalez-Garcia, C; Bravo, B; Ballester, A; Gomez-Perez, R; Eguiluz, C; Redondo, M; Martinez, A; Gil, C; Ballester, S
BRITISH JOURNAL OF PHARMACOLOGY2013170, 602-613  (ir a revista) 

"Multipotent, Permeable Drug ASS234 Inhibits A beta Aggregation, Possesses Antioxidant Properties and Protects from A beta-induced Apoptosis In Vitro" 
Bolea, I; Gella, A; Monjas, L; Perez, C; Rodriguez-Franco, MI; Marco-Contelles, J; Samadi, A; Unzeta, M
CURRENT ALZHEIMER RESEARCH201310, 797-808    ISSN: 1567-2050

"Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: New dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease" 
Samadi, A; Revenga, MD; Perez, C; Iriepa, I; Moraleda, I; Rodriguez-Franco, MI; Marco-Contelles, J
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY201367, 64-74  (ir a revista) 

"beta-N-methylamino-L-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS" 
de Munck, E; Munoz-Saez, E; Miguel, BG; Solas, MT; Ojeda, I; Martinez, A; Gil, C; Arahuetes, RM
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY201336, 243-255  (ir a revista) 

"Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival" 
Medina-Rodriguez, EM; Arenzana, FJ; Pastor, J; Redondo, M; Palomo, V; de Sola, RG; Gil, C; Martinez, A; Bribian, A; de Castro, F
CELLULAR AND MOLECULAR LIFE SCIENCES201370, 3449-3462  (ir a revista) 

"Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease" 
Perez-Gonzalez, R; Pascual, C; Antequera, D; Bolos, M; Redondo, M; Perez, DI; Perez-Grijalba, V; Krzyzanowska, A; Sarasa, M; Gil, C; Ferrer, I; Martinez, A; Carro, E
NEUROBIOLOGY OF AGING201334, 2133-2145  (ir a revista) 

"Lessons Learnt from Glycogen Synthase Kinase 3 Inhibitors Development for Alzheimer's Disease" 
Martinez, A; Perez, DI; Gil, C
CURRENT TOPICS IN MEDICINAL CHEMISTRY201313, 1808-1819    ISSN: 1568-0266

"The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox" 
Prieto, P; Kinsner-Ovaskainen, A; Stanzel, S; Albella, B; Artursson, P; Campillo, N; Cecchelli, R; Cerrato, L; Diaz, L; Di Consiglio, E; Guerra, A; Gombau, L; Herrera, G; Honegger, P; Landry, C; O'Connor, JE; Paez, JA; Quintas, G; Svensson, R; Turco, L; Zurich, MG; Zurbano, MJ; Kopp-Schneider, A
TOXICOLOGY IN VITRO201327, 1357-1376  (ir a revista) 

"INHIBITION OF ENDOGENOUS PHOSPHODIESTERASE 7 PROMOTES OLIGODENDROCYTE PRECURSOR SURVIVAL AND DIFFERENTIATION" 
Medina-Rodriguez, EM; Arenzana, FJ; Pastor, J; Redondo, M; Palomo, V; de Sola, RG; Gill, C; Martinez, A; Bribian, A; de Castro, F
GLIA201361, S57-S57   ISSN: 0894-1491

"Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3" 
Beurel, E; Kaidanovich-Beilin, O; Yeh, WI; Song, L; Palomo, V; Michalek, SM; Woodgett, JR; Harrington, LE; Eldar-Finkelman, H; Martinez, A; Jope, RS
JOURNAL OF IMMUNOLOGY2013190, 5000-5011  (ir a revista) 

"Microwave-Assisted Solid-Phase Synthesis of a 1,2-Disubstituted Benzimidazole Library by Using a Phosphonium Linker" 
Rios, N; Chavarria, C; Gil, C; Porcal, W
JOURNAL OF HETEROCYCLIC CHEMISTRY201350, 720-726  (ir a revista) 

"Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-beta-Induced Neurotoxicity" 
Silva, D; Chioua, M; Samadi, A; Agostinho, P; Garcao, P; Lajarin-Cuesta, R; de los Rios, C; Iriepa, I; Moraleda, I; Gonzalez-Lafuente, L; Mendes, E; Perez, C; Rodriguez-Franco, MI; Marco-Contelles, J; Carreiras, MC
ACS CHEMICAL NEUROSCIENCE20134, 547-565  (ir a revista) 

"Artificial Neural Networks Based on CODES Descriptors in Pharmacology: Identification of Novel Trypanocidal Drugs against Chagas Disease" 
Guerra, A; Gonzalez-Naranjo, P; Campillo, NE; Cerecetto, H; Gonzalez, M; Paez, JA
CURRENT COMPUTER-AIDED DRUG DESIGN20139, 130-140   ISSN: 1573-4099

"Multitarget Cannabinoids as Novel Strategy for Alzheimer Disease" 
Gonzalez-Naranjo, P; Campillo, NE; Perez, C; Paez, JA
CURRENT ALZHEIMER RESEARCH201310, 229-239    ISSN: 1567-2050

"Glycogen Synthase Kinase-3 Inhibitors as Potent Therapeutic Agents for the Treatment of Parkinson Disease." 
Morales-Garcia, JA; Susin, C; Alonso-Gil, S; Perez, DI; Palomo, V; Perez, C; Conde, S; Santos, A; Gil, C; Martinez, A; Perez-Castillo, A
ACS CHEMICAL NEUROSCIENCE20134, 350-360  (ir a revista) 

"A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer´s and Prion Diseases" 
Staderini, M; Aulic, S; Bartolini, M; Hoang, NAT; Gonzalez-Ruiz, V; Perez, DI; Cabezas, N; Martinez, A; Martin, MA; Andrisano, V; Legname, G; Menendez, JC; Bolognesi, ML
ACS MEDICINAL CHEMISTRY LETTERS20134, 225-229  (ir a revista) 

"Simvastatin prevents the induction of interleukin-6 gene expression by titanium particles in human osteoblastic cells" 
Valles, G; Perez, C; Bore, A; Martin-Saavedra, F; Saldana, L; Vilaboa, N
ACTA BIOMATERIALIA20139, 4916-4925  (ir a revista) 

"Dual inhibitor of PDE7 and GSK-3-VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice" 
Lipina, T V; Palomo, V; Gil, C; Martinez, A; Roder, JC
NEUROPHARMACOLOGY201364, 205-214  (ir a revista) 

"Adiponectin promoter activator NP-1 reduces body weight and hepatic steatosis in high-fat diet-fed animals" 
Serrano, A.; Pavon, F. J.; Suarez, J.; Rivera, P.; Vida, M.; Bermudez-Silva, F. J.; Alonso, M.; Martinez, A.; Lopez-Ogalla, J.; Alonso-Gascon, M.; Santamaria, G.; Romero-Cuevas, M.; Perez-Valero, V.; Baixeras, E.; Rodriguez de Fonseca, F.
Am. J. Physiol. Endocrinol. Metab2012302, E817-E830  (ir a revista) 

"Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress" 
Chavarría, C.; Perez, D. I.; Perez, C.; Morales Garcia, J. A.; Alonso-Gil, S.; Pérez-Castillo, A.; Gil, C.; Souza, J. M.; Porcal, W.
Eur. J. Med. Chem201258, 44-49  (ir a revista) 

"Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo" 
Morales-Garcia, JA; Luna-Medina, R; Alonso-Gil, S; Sanz-SanCristobal, M; Palomo, V; Gil, C; Santos, A; Martinez, A; Perez-Castillo, A
ACS CHEMICAL NEUROSCIENCE20123, 963-971  (ir a revista) 

"Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer´s disease: Synthesis, biological assessment, and molecular modeling" 
Samadi, A; Estrada, M; Perez, C; Rodriguez-Franco, MI; Iriepa, I; Moraleda, I; Chioua, M; Marco-Contelles, J
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY201257, 296-301  (ir a revista) 

"Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on A beta accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer´s disease" 
Antequera, D; Bolos, M; Spuch, C; Pascual, C; Ferrer, I; Fernandez-Bachiller, MI; Rodriguez-Franco, MI; Carro, E
NEUROBIOLOGY OF DISEASE201246, 682-691  (ir a revista) 

"Benzothiazepine CGP37157 and Its Isosteric 2 ´-Methyl Analogue Provide Neuroprotection and Block Cell Calcium Entry" 
Gonzalez-Lafuente, L; Egea, J; Leon, R; Martinez-Sanz, FJ; Monjas, L; Perez, C; Merino, C; Garcia-De Diego, AM; Rodriguez-Franco, MI; Garcia, AG; Villarroya, M; Lopez, MG; de los Rios, C
ACS CHEMICAL NEUROSCIENCE20123,  519-529  (ir a revista) 

"Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer´s disease" 
Maalej, E; Chabchoub, F; Oset-Gasque, MJ; Esquivias-Perez, M; Gonzalez, MR; Monjas, L; Perez, C; Rios, CDL; Rodriguez-Franco, MI; Iriepa, I; Moraleda, I; Chioua, M; Romero, A; Marco-Contelles, J; Samadi, A
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY201254, 750-763   

"The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury" 
Susin, C; Morales-Garcia, JA; Aguilar-Morante, D; Palomo, V; Sanz-Sancristobal, M; Alonso-Gil, S; Gil, C; Santos, A; Martinez, A; Perez-Castillo, A
JOURNAL OF NEUROCHEMISTRY2012122, 1193-1202  (ir a revista) 

"Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice." 
Redondo, M; Palomo, V; Brea, J; Perez, D I; Martin-Alvarez, R; Perez, C; Paul-Fernandez, N; Conde, S; Cadavid, M I; Loza, M I; Mengod, G; Martinez, A; Gil, C; Campillo, N E
ACS chemical neuroscience20123, 793-803  (ir a revista) 

"Benzothiazepine CGP37157 and its isosteric 2’-methyl analogue provide neuroprotection and block cell calcium entry" 
González-Lafuente, L; Egea, J.; León, R; Martínez-Sanz, F J; Monjas, L; Pérez, C; Merino, C; García De Diego, A M; Rodríguez-Franco, M I; García, A G; Villarroya, M; López, M G; de los Ríos, C
ACS Chem. Neurosci.20120,   (ir a revista) 

"Amidines bearing benzofuroxan or benzimidazole 1,3-dioxide core scaffolds as Trypanosoma cruzi-inhibitors: structural basis for their interactions with cruzipain" 
Merlino, A; Benitez, D; Campillo, NE; Paez, JA; Tinoco, LW; Gonzalez, M; Cerecetto, H
MEDCHEMCOMM20123, 90-101  (ir a revista) 

"Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model" 
Redondo, M; Zarruk, JG; Ceballos, P; Perez, DI; Perez, C; Perez-Castillo, A; Moro, MA; Brea, J; Val, C; Cadavid, MI; Loza, MI; Campillo, NE; Martinez, A; Gil, C
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY201247, 175-185  (ir a revista) 

"alpha-Aryl-N-alkyl Nitrones, as Potential Agents for Stroke Treatment: Synthesis, Theoretical Calculations, Antioxidant, Anti-inflammatory, Neuroprotective, and Brain-Blood Barrier Permeability Properties" 
Chioua, M; Sucunza, D; Soriano, E; Hadjipavlou-Litina, D; Alcazar, A; Ayuso, I; Oset-Gasque, MJ; Gonzalez, MP; Monjas, L; Rodriguez-Franco, MI; Marco-Contelles, J; Samadi, A
JOURNAL OF MEDICINAL CHEMISTRY201255, 153-168  (ir a revista) 

"Huprine-Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer´s and Prion Diseases" 
Galdeano, C; Viayna, E; Sola, I; Formosa, X ; Camps, P; Badia, A; Clos, MV; Relat, J ; Ratia, M; Bartolini, M; Mancini, F; Andrisano, V; Salmona, M; Minguillon, C; Gonzalez-Munoz, GC; Rodriguez-Franco, MI; Bidon-Chanal, A; Luque, FJ; Munoz-Torrero, D
JOURNAL OF MEDICINAL CHEMISTRY201255, 661-669  (ir a revista) 

"A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation" 
Chiriano, G; De Simone, A; Mancini, F; Perez, DI; Cavalli, A; Bolognesi, ML; Legname, G; Martinez, A; Andrisano, V; Carloni, P; Roberti, M
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY201248, 206-213  (ir a revista) 

"New Tacrine-4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer´s Disease, with Cholinergic, Antioxidant, and beta-Amyloid-Reducing Properties" 
Fernandez-Bachiller, MI; Perez, C; Monjas, L; Rademann, J; Rodriguez-Franco, MI
JOURNAL OF MEDICINAL CHEMISTRY201255, 1303-1317  (ir a revista) 

"5-Imino-1,2,4-Thiadiazoles: First Small Molecules As Substrate Competitive Inhibitors of Glycogen Synthase Kinase 3" 
Palomo, V; Perez, DI; Perez, C; Morales-Garcia, JA; Soteras, I; Alonso-Gil, S; Encinas, A; Castro, A; Campillo, NE; Perez-Castillo, A; Gil, C; Martinez, A
JOURNAL OF MEDICINAL CHEMISTRY201255, 1645-1661  (ir a revista) 

"5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3 beta (GSK-3 beta) and phosphodiesterase 7 (PDE7) inhibitors: Determination of blood-brain barrier penetration and binding to human serum albumin" 
Perez, DI; Pistolozzi, M; Palomo, V; Redondo, M; Fortugno, C; Gil, C ; Felix, G; Martinez, A; Bertucci, C
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES201245, 677-684  (ir a revista) 

"Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds" 
Redondo, M; Brea, J; Perez, DI; Soteras, I; Val, C; Perez, C; Morales-Garcia, JA; Alonso-Gil, S; Paul-Fernandez, N; Martin-Alvarez, R; Cadavid, MI; Loza, MI; Perez-Castillo, A; Mengod, G; Campillo, NE; Martinez, A; Gil, C
JOURNAL OF MEDICINAL CHEMISTRY201255, 3274-3284  (ir a revista)