Evolution in non-peptide α–helix mimetics on the road to effective protein-protein interaction modulators.
Algar, S.; Martín-Martínez, M.; González-Muñiz, R.
Eur. J. Med. Chem. 2021, 211, 113015; https://doi.org/10.1016/j.ejmech.2020.113015.
Phenylalanine-derived β-Lactam TRPM8 modulators. Configuration effect on the antagonist activity
Bonache, M.A.; Llabrés, P.J.; Martín-Escura, C.; De la Torre-Martínez, R.; Medina-Peris, A.; Gómez-Monterrey, I.; Roa, A.M.; Fernández-Ballester, G.; Ferrer-Montiel, A.; Fernández-Carvajal, A.; González-Muñíz, R.
Int. J. Mol. Sci., 2021, 22, 3390; https://doi.org/10.3390/ijms22052370.
Pharmacological Approaches for the Modulation of the Potassium Channel Kv4.x and KChIPs.
Cercós, D. A. Peraza, A.Benito-Bueno, P. G. Socuéllamos, A. Aziz-Nignan, D. Arrechaga-Estévez, E. Beato, E. Peña-Acevedo, A. Albert, J. A. González-Vera, Y. Rodríguez, M. Martín-Martínez, C. Valenzuela and M. Gutiérrez-Rodríguez
Int. J. Mol. Sci. 2021, 22(3), 1419; https://doi.org/10.3390/ijms22031419.
Natural Polyhydroxy Flavonoids, Curcuminoids and Synthetic Curcumin Analogs, as α7 nAChRs Positive Allosteric Modulators.
Ximenis, M.; Mulet, J.; Sala, S.; Sala, F.; Criado, M.; González-Muñíz, R. Pérez de Vega, M.J.
Int. J.Mol. Sci., 2021, 22, 973. https:// doi.org/10.3390/ijms22020973.
Investigational drugs in early phase clinical trials targeting thermoTRP channels.
Fernández-Carvajal, A.; González-Muñiz, R.; Fernádez-Ballester, G.; Ferrer-Montiel, A.
Expert Opin. Inv. Drugs 2020, 29, 1209–1222; https://doi.org/10.1080/13543784.2020.1825680.
Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity.
LLabrés, P.J.; Bonache, M.A.; Martín-Escura, C.; De la Torre-Martínez, R.; Fernández-Carvajal, A.; Fernández-Ballester, G.; Ferrer-Montiel, A.; González-Muñiz, R. Sci. Rep. 2020, 10, 14154.
Characterization of Novel Synthetic Polyphenols: Validation of Antioxidant and Vasculoprotective Activities.
Pérez de Vega, M.J. Moreno-Fernádez, S.; Pontes-Quero, G.M.; González-Amor, M.; Vázquez-Lasa, B.; Sabater-Muñoz, B.; Briones, A.M.; Aguilar, M.R.; Miguel, M.; González-Muñiz, R. Antioxidants 2020, 9(9), 787.
Smart lanthanide antennas for sensing water.
Fueyo-Gonzalez, F.; Garcia-Fernandez, E.; Martinez, D.; Infantes, L.; Orte, A.; Gonzalez-Vera, J. A.; Herranz, R. Chem. Commun. 2020, 56(41), 5484-5487.
Recent Progress in TRPM8 modulation: An update.
González-Muñiz, R., Bonache, M.A.; Martín-Escura, C.; Gómez Monterrey, I. Int. J. Mol. Sci. 2019, 20, E2618.
1-(2’,5’-Dihydroxyphenyl)-3-(2-fluoro-4-methoxyphenyl)-1-propanone: A positive allosteric modulator of a7 nicotinic receptors with analgesic and neuroprotective activity.
Pérez de Vega, M.J.; Fernandez Mendivil, C.; de la Torre Martínez, R.; González-Rodríguez,S.; Mullet, J.; Sala, F.; Sala, S.;Criado, M.; Moreno-Fernández, S.; Miguel, M.; Fernández-Carvajal, A.; Ferrer-Montiel, A.; García López, M.; González-Muñiz, R. ACS Chem. Neurochem. 2019, 10 (8), 3900-3909.
Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington’s disease treatment.
Lopez-Hurtado, A.; Peraza, D.A.; Cercos, P.; Lagartera, L..; Gonzalez, P; Dopazo, X.M.; Herranz R.; Gonzalez, T.; Martin-Martinez,, M;. Mellström B;. Naranjo, J.R.; Valenzuela, C.; Gutierrez-Rodriguez ,M.
Sci. Rep. 2019 , 9, 7260. DOI: 10.1038/s41598-019-43677-7.
Identification of IQM-266, a novel DREAM ligand that modulates KV4 currents D.A. Peraza, P. Cercós, P. Miaja, Y. G. Merinero, L. Lagartera, P. G. Socuéllamos, C. Izquierdo García, S. A. Sánchez, A. López-Hurtado, M. Martín-Martínez, L. A. Olivos-Oré, J. R. Naranjo, A. R. Artalejo, M. Gutiérrez-Rodríguez and C. Valenzuela.
Front. Mol. Neurosci. 2019, 12, 11. DOI: 10.3389/fnmol.2019.00011
Small library of triazolyl polyphenols correlating antioxidant activity and stability with the number and position of hydroxyl groups M.A. Bonache, S. Moreno-Fernández, M. Miguel, B. Sabater-Muñoz, R. González-Muñiz
ACS Comb. Sci. 2018, 20, 694-699. DOI: 10.1021/acscombsci.8b00118
Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity Balsera, J. Mulet, S. Sala, F Sala, R de la Torre, S. González-Rodríguez, A. Plata, L. Naesens, A. Fernández-Carvajal, A. Ferrer-Montiel, M. Criado, M. J. Pérez de Vega, R. González-Muñiz
Eur. J. Med. Chem. 2018, 143, 157-165. DOI: 10.1016/j.ejmech.2017.10.083
Synthesis, high-throughput screening and pharmacological characterization of β–lactam derivatives as TRPM8 antagonists R. de la Torre-Martínez, M. Angeles Bonache, P. J. Llabrés-Campaner, B. Balsera, A. Fernández-Carvajal, G. Fernández-Ballester, A. Ferrer-Montiel, M. J. Pérez de Vega, R. González-Muñiz
Sci. Rep. 2017, 7: 10766. DOI: 10.1038/s41598-017-10913-x
Modulating mineralocorticoid receptor with non-steroid antagonists. New opportunities for the development of potent and selective LBD ligands without off-target side-effects. M. Martín Martínez, F. Gordillo, D. Álvarez de la Rosa, Y. Rodríguez, G. Gerona Navarro, R. González Muñiz, M.-M. Zhou
Med. Chem. (Perspective) 2017, 60, 2629-2650.
DOI: 10.1021/acs.jmedchem.6b01065
Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer M.J. Pérez de Vega, I. Gómez-Monterrey, A. Ferrer-Montiel, R. González-Muñiz
Med. Chem. (Perspective) 2016, 59(22), 10006-10029.
DOI: 10.1021/acs.jmedchem.6b00305
1,3-Diphenylpropan-1-ones as Allosteric Modulators of α7 nACh Receptors with Analgesic and Antioxidant Properties M. Criado*, B. Balsera, J. Mulet, S. Sala, F. Sala, R. de la Torre-Martínez, A. Fernández-Carvajal, A. Ferrer-Montiel, S. Moreno-Fernández, M. Miguel, M. J. Pérez de Vega, R. González-Muñiz.
Future Med. Chem. 2016, 8, 731-749. DOI: 10.4155/fmc-2015-0001
Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes. J.A. Gonzalez-Vera, F. Fueyo-Gonzalez, I. Alkorta, M. Peyressatre, M. C Morris, R. Herranz.
Chem. Comm. 2016, 52, 9652-9655. DOI: 10.1039/c6cc04566a
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease. J.R. Naranjo, H. Zhang, D. Villar, P. González, X.M. Dopazo, J. Morón-Oset, E. Higueras, J.C. Oliveros, M.D. Arrabal, A. Prieto, P. Cercós, T. González, A. De la Cruz, J. Casado-Vela, A. Rábano, C. Valenzuela, M. Gutierrez-Rodriguez, J. Y. Li, B. Mellström.
Clin. Invest. 2016,126, 627-638. DOI: 10.1172/JCI82670.
Experimental and Theoretical Studies on the Rearrangement of 2- Oxoazepane α,α-Amino Acids into 2’-Oxopiperidine β2,3,3-Amino Acids: An Example of Intramolecular Catalysis D. Núñez-Villanueva, M.A. Bonache L. Lozano, L. Infantes, J. Elguero, I. Alkorta, M.T. García-López,R. González-Muñiz, M. Martín-Martínez
Chemisty: A Eur. J. 2015, 21, 2489-2500. DOI: 10.1002/chem.201405640