The Institute of Medicinal Chemistry (IQM) was founded in 1973 and belongs to the Spanish Research Council (CSIC). The institute is located at the Organic Chemistry Centre “Lora-Tamayo”. We focus our activity on the discovery and optimisation of bioactive molecules for treatment, characterisation and diagnosis of different diseases
We apply chemical approaches to solve biomedical problems that cover a wide variety of pathologies, from cancer to neurodegenerative, infectious and cardiovascular diseases. br>
Our research groups have extensive experience in chemical synthesis, molecular modeling, computational chemistry, study of interactions with biomolecules and nanotechnology
Iribarren, I, Sánchez-Sanz, G, Alkorta, I, Elguero, J, Trujillo, C. Evaluation of Electron Density Shifts in Noncovalent Interactions. J Phys Chem A. 2021;125 (22):4741-4749. doi: 10.1021/acs.jpca.1c00830. PubMed PMID:34061527 .
Alkorta, I, Legon, AC. The Electrophilicities of XCF3 and XCl (X=H, Cl, Br, I) and the Propensity of These Molecules To Form Hydrogen and Halogen Bonds with Lewis Bases: An Ab Initio Study. Chempluschem. 2021;86 (5):778-784. doi: 10.1002/cplu.202100088. PubMed PMID:33988921 .