Phytocannabinoids, also called natural cannabinoids or classical cannabinoids, are a group of naturally occurring compounds isolated mainly from the plant Cannabis sativa L. These compounds are concentrated in a viscous resin that is produced in glandular structures known as trichomes. The main component is Δ9-THC, which was isolated and characterized in 1964. This compound is responsible for the psychoactive properties of cannabis, although it has many other therapeutic properties, such as analgesic, anti-inflammatory, antiemetic, muscle relaxant, antiasmatic, antispasmodic and antiproliferative. There are more than 70 cannabinoid compounds isolated from Cannabis sativa having different agonist and antagonist properties over cannabinoid receptors (CB1 and CB2).