As a first work in the cannabinoid field we carried out a modeling study of CBRs, using the X-ray structure of bovine Rodopsine (pdb code: 1f88) as structural template. Docking studies with the most representative cannabinoids, described as partial agonists or antagonists / inverse agonists, were performed. The results confirmed the existence of two binding sites on both receptors. While in the CB1R was observed a clear overlap of both sites, in CB2R, the sites are clearly distinct. In both sites, receptor-ligand interactions are governed by a combination of hydrogen bonds and aromatic interactions.
Entradas recientes
Archivos
Categorías
- Anti-T. cruzi Drug Design
- Cannabinoid Receptors
- Cannabis sativa
- Chagas Disease
- Collaborations
- Collaborations_cd
- Concepción Pérez
- Cruzain Inhibitors
- Docking Studies
- Drugs Against Chagas Disease
- Endocannabinoid System
- Homology Modeling
- Juan A. Páez
- Neurodegenerative diseases
- Nuria E. Campillo
- Strategy of Drug Design
- Synthetic Cannabinoids
- The Parasite: Trypanosoma Cruzi
- Transmission of Chagas Disease
- Trypanosoma cruzi
- version_flash
Comentarios recientes